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HHcy is considered a risk factor for AD, as it affects processes such as DNA methylation and repair, oxidative stress, amyloid aggregation, tau phosphorylation, vascular endothelial dysfunction, and the secretion of inflammatory mediators like tumor necrosis factor (TNF), nuclear factor B, interleukin 6 (IL-6), and interleukin 8 (IL-8) [86]

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During TNF--induced apoptosis in hepatocytes, hydrogen peroxide is an important mediator of cell death (Bohler et al., 2000)

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